Drug interactions
Carisoprodol + Sufentanil
Severity: Major
Carisoprodol and Sufentanil: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with carisoprodol cause additive sedation and respiratory depression. Profound sedation, respiratory failure or death can occur.
What this interaction means in plain words
Carisoprodol and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carisoprodol belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression.
What to do
Avoid where possible; if used together, reduce doses and monitor respiratory rate and sedation continuously.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Carisoprodol
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Carisoprodol with Sufentanil?
MediHelp rates the interaction as major. Carisoprodol and Sufentanil can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with carisoprodol cause additive sedation and respiratory depression. Profound sedation, respiratory failure or death can occur.
How serious is the interaction between Carisoprodol and Sufentanil?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid where possible; if used together, reduce doses and monitor respiratory rate and sedation continuously.
What other medicines interact with Carisoprodol?
MediHelp also lists interactions of Carisoprodol with, for example, Alfentanil, Alprazolam, Amobarbital. The full list is on the Carisoprodol page.
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