Drug interactions
Carvedilol + Celecoxib
Severity: Moderate
Carvedilol and Celecoxib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may blunt the blood pressure lowering effect of carvedilol. Celecoxib is a weak CYP2D6 inhibitor, but a clinically important rise in carvedilol levels is not established.
What this interaction means in plain words
Carvedilol and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Celecoxib belongs to Musculoskeletal.
Why it happens
Prostaglandin synthesis inhibition causes sodium and water retention and attenuates vasodilation, opposing beta-blocker effect.
What to do
Monitor blood pressure and heart failure signs such as fluid retention, and adjust therapy if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Celecoxib?
MediHelp rates the interaction as moderate. Carvedilol and Celecoxib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib may blunt the blood pressure lowering effect of carvedilol. Celecoxib is a weak CYP2D6 inhibitor, but a clinically important rise in carvedilol levels is not established.
How serious is the interaction between Carvedilol and Celecoxib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart failure signs such as fluid retention, and adjust therapy if control worsens.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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