Drug interactions
Carvedilol + Cimetidine
Severity: Minor
Carvedilol and Cimetidine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cimetidine can modestly increase carvedilol exposure. This may lead to greater bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Cimetidine belongs to Gastrointestinal Tract.
Why it happens
Cimetidine inhibits CYP2D6 and CYP2C9 metabolism of carvedilol and may also reduce hepatic blood flow.
What to do
Monitor heart rate and blood pressure when starting or stopping cimetidine. Adjust carvedilol dose if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Cimetidine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cimetidine
- Cimetidine + Dofetilide Contraindicated
- Cimetidine + Fezolinetant Contraindicated
- Alfentanil + Cimetidine Major
- Atazanavir + Cimetidine Major
- Carmustine + Cimetidine Major
- Cimetidine + Citalopram Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Cimetidine?
MediHelp rates the interaction as minor. Carvedilol and Cimetidine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cimetidine can modestly increase carvedilol exposure. This may lead to greater bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Cimetidine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping cimetidine. Adjust carvedilol dose if symptomatic.
What other medicines interact with Cimetidine?
MediHelp also lists interactions of Cimetidine with, for example, Dofetilide, Fezolinetant, Alfentanil. The full list is on the Cimetidine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
