Drug interactions
Carvedilol + Duvelisib
Severity: Minor
Carvedilol and Duvelisib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is a P-gp inhibitor and could modestly raise duvelisib exposure, but duvelisib is mainly cleared by CYP3A4 and the clinical relevance is unestablished.
What this interaction means in plain words
Carvedilol and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Duvelisib belongs to Oncology.
Why it happens
Possible P-gp inhibition by carvedilol; not well characterised.
What to do
No routine dose change; monitor for duvelisib toxicity such as diarrhea, rash and infection.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Avanafil + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
Frequently asked questions
Can I take Carvedilol with Duvelisib?
MediHelp rates the interaction as minor. Carvedilol and Duvelisib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carvedilol is a P-gp inhibitor and could modestly raise duvelisib exposure, but duvelisib is mainly cleared by CYP3A4 and the clinical relevance is unestablished.
How serious is the interaction between Carvedilol and Duvelisib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine dose change; monitor for duvelisib toxicity such as diarrhea, rash and infection.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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