Drug interactions
Avanafil + Duvelisib
Severity: Major
Avanafil and Duvelisib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Duvelisib inhibits CYP3A4 and may increase avanafil exposure, raising the risk of hypotension, headache, flushing and priapism. Avanafil is a sensitive CYP3A4 substrate, so the effect may be substantial.
What this interaction means in plain words
Avanafil and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Avanafil belongs to Genitourinary; Duvelisib belongs to Oncology.
Why it happens
Duvelisib inhibits CYP3A4, decreasing avanafil metabolism.
What to do
Use the lowest effective avanafil dose, not exceeding labeled limits for CYP3A4 inhibitors, and monitor blood pressure. Consider an alternative if tolerability is poor.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Avanafil
- Amyl nitrite + Avanafil Contraindicated
- Atazanavir + Avanafil Contraindicated
- Avanafil + Clarithromycin Contraindicated
- Avanafil + Conivaptan Contraindicated
- Avanafil + Darunavir Contraindicated
- Avanafil + Fosamprenavir Contraindicated
Other interactions of Duvelisib
- Duvelisib + Ergotamine Contraindicated
- Alfuzosin + Duvelisib Major
- Apalutamide + Duvelisib Major
- Carbamazepine + Duvelisib Major
- Chloramphenicol + Duvelisib Major
- Clarithromycin + Duvelisib Major
Frequently asked questions
Can I take Avanafil with Duvelisib?
MediHelp rates the interaction as major. Avanafil and Duvelisib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Duvelisib inhibits CYP3A4 and may increase avanafil exposure, raising the risk of hypotension, headache, flushing and priapism. Avanafil is a sensitive CYP3A4 substrate, so the effect may be substantial.
How serious is the interaction between Avanafil and Duvelisib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective avanafil dose, not exceeding labeled limits for CYP3A4 inhibitors, and monitor blood pressure. Consider an alternative if tolerability is poor.
What other medicines interact with Avanafil?
MediHelp also lists interactions of Avanafil with, for example, Amyl nitrite, Atazanavir, Clarithromycin. The full list is on the Avanafil page.
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