Drug interactions
Carvedilol + Enalapril-hydrochlorothiazide
Severity: Minor
Carvedilol and Enalapril-hydrochlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol adds to the blood pressure lowering effect of enalapril and hydrochlorothiazide, which can cause excessive hypotension, dizziness or syncope, especially at initiation. This combination is often used intentionally in hypertension and heart failure.
What this interaction means in plain words
Carvedilol and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Enalapril-hydrochlorothiazide belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic antihypertensive effects through beta and alpha blockade combined with ACE inhibition and diuresis.
What to do
Start carvedilol at a low dose and titrate gradually while monitoring blood pressure and heart rate. Check serum potassium and renal function periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Enalapril-hydrochlorothiazide
- Aliskiren + Enalapril-hydrochlorothiazide Contraindicated
- Dofetilide + Enalapril-hydrochlorothiazide Contraindicated
- Enalapril-hydrochlorothiazide + Protein a column Contraindicated
- Enalapril-hydrochlorothiazide + Sacubitril / valsartan Contraindicated
- Amifostine + Enalapril-hydrochlorothiazide Major
- Amiloride + Enalapril-hydrochlorothiazide Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Enalapril-hydrochlorothiazide?
MediHelp rates the interaction as minor. Carvedilol and Enalapril-hydrochlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carvedilol adds to the blood pressure lowering effect of enalapril and hydrochlorothiazide, which can cause excessive hypotension, dizziness or syncope, especially at initiation. This combination is often used intentionally in hypertension and heart failure.
How serious is the interaction between Carvedilol and Enalapril-hydrochlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start carvedilol at a low dose and titrate gradually while monitoring blood pressure and heart rate. Check serum potassium and renal function periodically.
What other medicines interact with Enalapril-hydrochlorothiazide?
MediHelp also lists interactions of Enalapril-hydrochlorothiazide with, for example, Aliskiren, Dofetilide, Protein a column. The full list is on the Enalapril-hydrochlorothiazide page.
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