Drug interactions
Carvedilol + Fluticasone-vilanterol
Severity: Major
Carvedilol and Fluticasone-vilanterol: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is a non-selective beta-blocker that antagonises the bronchodilating effect of vilanterol. It may also provoke bronchospasm in patients with asthma or COPD.
What this interaction means in plain words
Carvedilol and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Carvedilol belongs to Cardiovascular; Fluticasone-vilanterol belongs to Respiratory.
Why it happens
Pharmacodynamic antagonism at beta-2 receptors by non-selective beta blockade.
What to do
Avoid carvedilol in asthma and use a cardioselective beta-1 blocker such as bisoprolol when a beta-blocker is needed. Monitor lung function and symptoms closely.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Fluticasone-vilanterol
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Fluticasone-vilanterol?
MediHelp rates the interaction as major. Carvedilol and Fluticasone-vilanterol can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Carvedilol is a non-selective beta-blocker that antagonises the bronchodilating effect of vilanterol. It may also provoke bronchospasm in patients with asthma or COPD.
How serious is the interaction between Carvedilol and Fluticasone-vilanterol?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid carvedilol in asthma and use a cardioselective beta-1 blocker such as bisoprolol when a beta-blocker is needed. Monitor lung function and symptoms closely.
What other medicines interact with Fluticasone-vilanterol?
MediHelp also lists interactions of Fluticasone-vilanterol with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Fluticasone-vilanterol page.
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