Drug interactions
Carvedilol + Hydrochlorothiazide-losartan
Severity: Minor
Carvedilol and Hydrochlorothiazide-losartan: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol adds alpha- and beta-blocking vasodilation to the ARB and thiazide, increasing the chance of hypotension, dizziness and bradycardia. It may also mask hypoglycemia symptoms. Losartan remains contraindicated in pregnancy.
What this interaction means in plain words
Carvedilol and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Hydrochlorothiazide-losartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive pharmacodynamic effects through different mechanisms.
What to do
Monitor blood pressure and heart rate and titrate doses gradually. Check potassium and renal function periodically.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Hydrochlorothiazide-losartan
- Aliskiren + Hydrochlorothiazide-losartan Contraindicated
- Dofetilide + Hydrochlorothiazide-losartan Contraindicated
- Hydrochlorothiazide-losartan + Sparsentan Contraindicated
- Aceclofenac + Hydrochlorothiazide-losartan Major
- Aldesleukin + Hydrochlorothiazide-losartan Major
- Amifostine + Hydrochlorothiazide-losartan Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Hydrochlorothiazide-losartan?
MediHelp rates the interaction as minor. Carvedilol and Hydrochlorothiazide-losartan have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Carvedilol adds alpha- and beta-blocking vasodilation to the ARB and thiazide, increasing the chance of hypotension, dizziness and bradycardia. It may also mask hypoglycemia symptoms. Losartan remains contraindicated in pregnancy.
How serious is the interaction between Carvedilol and Hydrochlorothiazide-losartan?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate and titrate doses gradually. Check potassium and renal function periodically.
What other medicines interact with Hydrochlorothiazide-losartan?
MediHelp also lists interactions of Hydrochlorothiazide-losartan with, for example, Aliskiren, Dofetilide, Sparsentan. The full list is on the Hydrochlorothiazide-losartan page.
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