Drug interactions
Carvedilol + Imatinib
Severity: Moderate
Carvedilol and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Imatinib inhibits CYP2D6 and CYP3A4 and may increase carvedilol concentrations. Higher exposure can intensify beta-blockade and vasodilation, leading to bradycardia or hypotension.
What this interaction means in plain words
Carvedilol and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Imatinib belongs to Oncology.
Why it happens
Imatinib inhibits CYP2D6 and CYP2C9, reducing carvedilol clearance.
What to do
Monitor heart rate and blood pressure when the combination is started or imatinib dosing changes. Lower the carvedilol dose if bradycardia or dizziness occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Frequently asked questions
Can I take Carvedilol with Imatinib?
MediHelp rates the interaction as moderate. Carvedilol and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Imatinib inhibits CYP2D6 and CYP3A4 and may increase carvedilol concentrations. Higher exposure can intensify beta-blockade and vasodilation, leading to bradycardia or hypotension.
How serious is the interaction between Carvedilol and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when the combination is started or imatinib dosing changes. Lower the carvedilol dose if bradycardia or dizziness occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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