Drug interactions
Carvedilol + Irbesartan
Severity: Moderate
Carvedilol and Irbesartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The combination lowers blood pressure additively and is commonly used in hypertension and heart failure. Angiotensin receptor blockade can raise serum potassium and affect renal function, and beta-blockers can modestly add to hyperkalaemia risk.
What this interaction means in plain words
Carvedilol and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Irbesartan belongs to Cardiovascular.
Why it happens
Additive antihypertensive effects, with reduced aldosterone-driven potassium excretion from irbesartan and impaired cellular potassium uptake with beta-blockade.
What to do
Monitor blood pressure, serum potassium and creatinine after starting or adjusting doses. Avoid additional potassium supplements or potassium-sparing agents unless monitored.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Irbesartan
- Aliskiren + Irbesartan Contraindicated
- Irbesartan + Sparsentan Contraindicated
- Amifostine + Irbesartan Major
- Amiloride + Irbesartan Major
- Amlodipine-benazepril + Irbesartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Irbesartan Major
Frequently asked questions
Can I take Carvedilol with Irbesartan?
MediHelp rates the interaction as moderate. Carvedilol and Irbesartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. The combination lowers blood pressure additively and is commonly used in hypertension and heart failure. Angiotensin receptor blockade can raise serum potassium and affect renal function, and beta-blockers can modestly add to hyperkalaemia risk.
How serious is the interaction between Carvedilol and Irbesartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, serum potassium and creatinine after starting or adjusting doses. Avoid additional potassium supplements or potassium-sparing agents unless monitored.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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