Drug interactions
Carvedilol + Ketoprofen
Severity: Moderate
Carvedilol and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Regular ketoprofen use can reduce the blood pressure lowering effect of carvedilol. The effect is most relevant with continued NSAID use over days to weeks.
What this interaction means in plain words
Carvedilol and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Ketoprofen belongs to Musculoskeletal.
Why it happens
NSAIDs inhibit vasodilatory prostaglandin synthesis, causing sodium and water retention that opposes the beta-blocker.
What to do
Monitor blood pressure when ketoprofen is used regularly with carvedilol and adjust antihypertensive therapy if needed. Use the shortest possible NSAID course.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Ketoprofen?
MediHelp rates the interaction as moderate. Carvedilol and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Regular ketoprofen use can reduce the blood pressure lowering effect of carvedilol. The effect is most relevant with continued NSAID use over days to weeks.
How serious is the interaction between Carvedilol and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when ketoprofen is used regularly with carvedilol and adjust antihypertensive therapy if needed. Use the shortest possible NSAID course.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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