Drug interactions
Carvedilol + Levodopa
Severity: Moderate
Carvedilol and Levodopa: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levodopa can cause orthostatic hypotension, and this may be additive with the vasodilating effects of carvedilol. Patients may experience dizziness, falls or syncope, especially when starting treatment or increasing doses.
What this interaction means in plain words
Carvedilol and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Levodopa belongs to Central Nervous System.
Why it happens
Additive hypotensive effects from levodopa-derived dopamine and carvedilol's alpha-1 blockade and beta-blockade.
What to do
Monitor sitting and standing blood pressure, especially at initiation or dose changes. Reduce the carvedilol dose if symptomatic orthostatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Levodopa
- Isocarboxazid + Levodopa Contraindicated
- Levodopa + Phenelzine Contraindicated
- Levodopa + Phenelzine (nonselective MAOI) Contraindicated
- Levodopa + Procarbazine Contraindicated
- Levodopa + Tranylcypromine Contraindicated
- Amisulpride + Levodopa Major
Frequently asked questions
Can I take Carvedilol with Levodopa?
MediHelp rates the interaction as moderate. Carvedilol and Levodopa can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levodopa can cause orthostatic hypotension, and this may be additive with the vasodilating effects of carvedilol. Patients may experience dizziness, falls or syncope, especially when starting treatment or increasing doses.
How serious is the interaction between Carvedilol and Levodopa?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sitting and standing blood pressure, especially at initiation or dose changes. Reduce the carvedilol dose if symptomatic orthostatic hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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