Drug interactions
Carvedilol + Naldemedine
Severity: Minor
Carvedilol and Naldemedine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naldemedine is a P-glycoprotein substrate, and carvedilol can inhibit P-gp. Naldemedine exposure may increase, which could enhance opioid-withdrawal-like gastrointestinal effects such as abdominal pain and diarrhea.
What this interaction means in plain words
Carvedilol and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Carvedilol inhibits P-gp efflux of naldemedine, raising its absorption.
What to do
No dose adjustment is usually needed. Monitor for abdominal pain, diarrhea and signs of opioid withdrawal.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Carvedilol
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
Frequently asked questions
Can I take Carvedilol with Naldemedine?
MediHelp rates the interaction as minor. Carvedilol and Naldemedine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Naldemedine is a P-glycoprotein substrate, and carvedilol can inhibit P-gp. Naldemedine exposure may increase, which could enhance opioid-withdrawal-like gastrointestinal effects such as abdominal pain and diarrhea.
How serious is the interaction between Carvedilol and Naldemedine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed. Monitor for abdominal pain, diarrhea and signs of opioid withdrawal.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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