Drug interactions
Naldemedine + Naltrexone
Severity: Major
Naldemedine and Naltrexone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Naltrexone is a systemic opioid antagonist and naldemedine is a peripheral one, so together they add opioid receptor blockade. Naldemedine is intended for patients taking opioids, who on naltrexone would have blocked analgesia, and withdrawal is possible.
What this interaction means in plain words
Naldemedine and Naltrexone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Naldemedine belongs to Gastrointestinal Tract; Naltrexone belongs to Musculoskeletal.
Why it happens
Additive opioid receptor antagonism.
What to do
Avoid the combination; naldemedine offers no benefit in a patient taking naltrexone. If opioid-induced constipation is present, review the need for opioids and choose a different laxative approach.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Naltrexone
- Naloxegol + Naltrexone Major
- Bremelanotide + Naltrexone Moderate
- Lofexidine + Naltrexone Moderate
- Acamprosate + Naltrexone Minor
- Apalutamide + Naltrexone Minor
- Dronabinol + Naltrexone Minor
Other interactions of Naldemedine
- Bupropion-naltrexone + Naldemedine Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
- Aprepitant + Naldemedine Moderate
Frequently asked questions
Can I take Naldemedine with Naltrexone?
MediHelp rates the interaction as major. Naldemedine and Naltrexone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Naltrexone is a systemic opioid antagonist and naldemedine is a peripheral one, so together they add opioid receptor blockade. Naldemedine is intended for patients taking opioids, who on naltrexone would have blocked analgesia, and withdrawal is possible.
How serious is the interaction between Naldemedine and Naltrexone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination; naldemedine offers no benefit in a patient taking naltrexone. If opioid-induced constipation is present, review the need for opioids and choose a different laxative approach.
What other medicines interact with Naltrexone?
MediHelp also lists interactions of Naltrexone with, for example, Naloxegol, Bremelanotide, Lofexidine. The full list is on the Naltrexone page.
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