Drug interactions
Bupropion-naltrexone + Naldemedine
Severity: Major
Bupropion-naltrexone and Naldemedine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both naltrexone and naldemedine are opioid receptor antagonists. Combined use may precipitate or worsen opioid withdrawal symptoms in patients on opioids, and naltrexone would also negate the purpose of naldemedine.
What this interaction means in plain words
Bupropion-naltrexone and Naldemedine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Bupropion-naltrexone belongs to Miscellaneous; Naldemedine belongs to Gastrointestinal Tract.
Why it happens
Additive opioid receptor antagonism, with central blockade by naltrexone and peripheral blockade by naldemedine.
What to do
Avoid concurrent use. Choose another approach to opioid-induced constipation, or reassess the need for bupropion-naltrexone.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Bupropion-naltrexone
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydromorphone Contraindicated
- Bupropion-naltrexone + Isocarboxazid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion-naltrexone + Phenelzine Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
Other interactions of Naldemedine
- Naldemedine + Naltrexone Major
- Naldemedine + Phenytoin Major
- Naldemedine + Rifampicin Major
- Amobarbital + Naldemedine Moderate
- Apalutamide + Naldemedine Moderate
- Aprepitant + Naldemedine Moderate
Frequently asked questions
Can I take Bupropion-naltrexone with Naldemedine?
MediHelp rates the interaction as major. Bupropion-naltrexone and Naldemedine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both naltrexone and naldemedine are opioid receptor antagonists. Combined use may precipitate or worsen opioid withdrawal symptoms in patients on opioids, and naltrexone would also negate the purpose of naldemedine.
How serious is the interaction between Bupropion-naltrexone and Naldemedine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use. Choose another approach to opioid-induced constipation, or reassess the need for bupropion-naltrexone.
What other medicines interact with Bupropion-naltrexone?
MediHelp also lists interactions of Bupropion-naltrexone with, for example, Hydrocodone, Hydromorphone, Isocarboxazid. The full list is on the Bupropion-naltrexone page.
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