Drug interactions
Carvedilol + Oxaprozin
Severity: Moderate
Carvedilol and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sustained oxaprozin use may weaken the blood pressure lowering effect of carvedilol. This may lead to worse hypertension control over time.
What this interaction means in plain words
Carvedilol and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Oxaprozin belongs to Musculoskeletal.
Why it happens
NSAID-induced inhibition of prostaglandin synthesis causes sodium and fluid retention and vasoconstriction, opposing the antihypertensive action.
What to do
Monitor blood pressure and heart failure symptoms if used together long term. Use the lowest effective NSAID dose or an alternative analgesic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Carvedilol and Oxaprozin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Oxaprozin?
MediHelp rates the interaction as moderate. Carvedilol and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sustained oxaprozin use may weaken the blood pressure lowering effect of carvedilol. This may lead to worse hypertension control over time.
How serious is the interaction between Carvedilol and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart failure symptoms if used together long term. Use the lowest effective NSAID dose or an alternative analgesic.
What other medicines interact with Oxaprozin?
MediHelp also lists interactions of Oxaprozin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Oxaprozin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
