Drug interactions
Carvedilol + Pilocarpine
Severity: Moderate
Carvedilol and Pilocarpine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pilocarpine is a muscarinic agonist, and beta-blockers may add to its effects on cardiac conduction. Bradycardia or conduction disturbances may occur, mainly with oral pilocarpine.
What this interaction means in plain words
Carvedilol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Pilocarpine belongs to Miscellaneous.
Why it happens
Additive pharmacodynamic effects on cardiac conduction from muscarinic stimulation and beta-blockade.
What to do
Monitor heart rate and watch for bradycardia or conduction block when oral pilocarpine is used with carvedilol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Pilocarpine
- Amitriptyline + Pilocarpine Moderate
- Atenolol-chlorthalidone + Pilocarpine Moderate
- Atenolol + Pilocarpine Moderate
- Atropine + Pilocarpine Moderate
- Betaxolol + Pilocarpine Moderate
- Bethanechol + Pilocarpine Moderate
Frequently asked questions
Can I take Carvedilol with Pilocarpine?
MediHelp rates the interaction as moderate. Carvedilol and Pilocarpine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pilocarpine is a muscarinic agonist, and beta-blockers may add to its effects on cardiac conduction. Bradycardia or conduction disturbances may occur, mainly with oral pilocarpine.
How serious is the interaction between Carvedilol and Pilocarpine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and watch for bradycardia or conduction block when oral pilocarpine is used with carvedilol.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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