Drug interactions
Carvedilol + Quinidine
Severity: Moderate
Carvedilol and Quinidine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinidine inhibits CYP2D6 and raises exposure to the R(+) enantiomer of carvedilol, which has beta-blocking activity. This may increase bradycardia, hypotension and dizziness, and both drugs can affect cardiac conduction.
What this interaction means in plain words
Carvedilol and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Quinidine belongs to Anti Parasitic.
Why it happens
Quinidine inhibits CYP2D6 metabolism of carvedilol, with additive effects on cardiac conduction.
What to do
Monitor heart rate, blood pressure and ECG, and reduce the carvedilol dose if bradycardia or hypotension develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Quinidine
- Adagrasib + Quinidine Contraindicated
- Arsenic trioxide + Quinidine Contraindicated
- Artemether / lumefantrine + Quinidine Contraindicated
- Chloroquine + Quinidine Contraindicated
- Dofetilide + Quinidine Contraindicated
- Dronedarone + Quinidine Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Quinidine?
MediHelp rates the interaction as moderate. Carvedilol and Quinidine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Quinidine inhibits CYP2D6 and raises exposure to the R(+) enantiomer of carvedilol, which has beta-blocking activity. This may increase bradycardia, hypotension and dizziness, and both drugs can affect cardiac conduction.
How serious is the interaction between Carvedilol and Quinidine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and reduce the carvedilol dose if bradycardia or hypotension develops.
What other medicines interact with Quinidine?
MediHelp also lists interactions of Quinidine with, for example, Adagrasib, Arsenic trioxide, Artemether / lumefantrine. The full list is on the Quinidine page.
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