Drug interactions
Carvedilol + Riociguat
Severity: Moderate
Carvedilol and Riociguat: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs lower blood pressure, so combined use can cause additive hypotension and dizziness. A clinically meaningful pharmacokinetic effect on riociguat from carvedilol is not established.
What this interaction means in plain words
Carvedilol and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Riociguat belongs to Cardiovascular.
Why it happens
Additive vasodilatory and blood pressure lowering effects (pharmacodynamic); carvedilol is not a recognized strong inhibitor of riociguat clearance.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the riociguat dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Riociguat
- Avanafil + Riociguat Contraindicated
- Dipyridamole + Riociguat Contraindicated
- Isosorbide dinitrate + Riociguat Contraindicated
- Isosorbide mononitrate + Riociguat Contraindicated
- Nitroglycerin + Riociguat Contraindicated
- Riociguat + Sildenafil Contraindicated
Frequently asked questions
Can I take Carvedilol with Riociguat?
MediHelp rates the interaction as moderate. Carvedilol and Riociguat can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs lower blood pressure, so combined use can cause additive hypotension and dizziness. A clinically meaningful pharmacokinetic effect on riociguat from carvedilol is not established.
How serious is the interaction between Carvedilol and Riociguat?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating either drug. Reduce the riociguat dose if symptomatic hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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