Drug interactions
Carvedilol + Ritonavir
Severity: Moderate
Carvedilol and Ritonavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir inhibits CYP2D6 and other pathways and may raise carvedilol concentrations. This can cause bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
Why it happens
Inhibition of CYP2D6 (and possibly P-gp) reduces carvedilol clearance.
What to do
Monitor heart rate and blood pressure when starting or stopping ritonavir and reduce the carvedilol dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Dronedarone + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
Frequently asked questions
Can I take Carvedilol with Ritonavir?
MediHelp rates the interaction as moderate. Carvedilol and Ritonavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ritonavir inhibits CYP2D6 and other pathways and may raise carvedilol concentrations. This can cause bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Ritonavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when starting or stopping ritonavir and reduce the carvedilol dose if needed.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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