Drug interactions
Dronedarone + Ritonavir
Severity: Contraindicated
Dronedarone and Ritonavir: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ritonavir is a potent CYP3A4 inhibitor and markedly raises dronedarone levels, increasing the risk of QT prolongation and torsades de pointes. Dronedarone may also modestly raise ritonavir exposure through P-glycoprotein inhibition.
What this interaction means in plain words
Dronedarone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Dronedarone belongs to Cardiovascular; Ritonavir belongs to Anti Virals.
Why it happens
Potent CYP3A4 inhibition by ritonavir reduces dronedarone clearance, with additional P-glycoprotein inhibition by dronedarone.
What to do
Do not coadminister; select an alternative antiarrhythmic or antiretroviral regimen.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Dronedarone
- Adagrasib + Dronedarone Contraindicated
- Amiodarone + Dronedarone Contraindicated
- Arsenic trioxide + Dronedarone Contraindicated
- Artemether / lumefantrine + Dronedarone Contraindicated
- Atazanavir + Dronedarone Contraindicated
- Azithromycin + Dronedarone Contraindicated
Other interactions of Ritonavir
- Alfuzosin + Ritonavir Contraindicated
- Amiodarone + Ritonavir Contraindicated
- Avanafil + Ritonavir Contraindicated
- Colchicine + Ritonavir Contraindicated
- Eletriptan + Ritonavir Contraindicated
- Eplerenone + Ritonavir Contraindicated
Frequently asked questions
Can I take Dronedarone with Ritonavir?
MediHelp rates the interaction as contraindicated. Dronedarone and Ritonavir are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Ritonavir is a potent CYP3A4 inhibitor and markedly raises dronedarone levels, increasing the risk of QT prolongation and torsades de pointes. Dronedarone may also modestly raise ritonavir exposure through P-glycoprotein inhibition.
How serious is the interaction between Dronedarone and Ritonavir?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not coadminister; select an alternative antiarrhythmic or antiretroviral regimen.
What other medicines interact with Dronedarone?
MediHelp also lists interactions of Dronedarone with, for example, Adagrasib, Amiodarone, Arsenic trioxide. The full list is on the Dronedarone page.
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