Drug interactions
Carvedilol + Secobarbital
Severity: Moderate
Carvedilol and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is an inducer of hepatic enzymes and may speed up the clearance of carvedilol. This can lower carvedilol exposure and weaken its blood pressure and heart rate control.
What this interaction means in plain words
Carvedilol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Secobarbital belongs to Central Nervous System.
Why it happens
Barbiturate induction of hepatic oxidative metabolism of carvedilol increases its clearance.
What to do
Monitor blood pressure and heart rate when secobarbital is started or stopped, and increase the carvedilol dose if control is lost. Reassess the dose after the barbiturate is withdrawn.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Carvedilol with Secobarbital?
MediHelp rates the interaction as moderate. Carvedilol and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital is an inducer of hepatic enzymes and may speed up the clearance of carvedilol. This can lower carvedilol exposure and weaken its blood pressure and heart rate control.
How serious is the interaction between Carvedilol and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate when secobarbital is started or stopped, and increase the carvedilol dose if control is lost. Reassess the dose after the barbiturate is withdrawn.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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