Drug interactions
Carvedilol + Sertraline
Severity: Moderate
Carvedilol and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sertraline can inhibit CYP2D6, particularly at higher doses, and carvedilol is partly cleared by this enzyme. Carvedilol exposure may rise modestly, increasing the likelihood of bradycardia, hypotension and dizziness.
What this interaction means in plain words
Carvedilol and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Sertraline belongs to Central Nervous System.
Why it happens
Sertraline inhibits CYP2D6 (dose-dependent, weak to moderate), reducing the metabolism of the R(+) enantiomer of carvedilol.
What to do
Monitor heart rate and blood pressure when sertraline is started or its dose is increased. Reduce the carvedilol dose if symptomatic bradycardia or hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Carvedilol with Sertraline?
MediHelp rates the interaction as moderate. Carvedilol and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sertraline can inhibit CYP2D6, particularly at higher doses, and carvedilol is partly cleared by this enzyme. Carvedilol exposure may rise modestly, increasing the likelihood of bradycardia, hypotension and dizziness.
How serious is the interaction between Carvedilol and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure when sertraline is started or its dose is increased. Reduce the carvedilol dose if symptomatic bradycardia or hypotension occurs.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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