Drug interactions
Carvedilol + Terbinafine
Severity: Moderate
Carvedilol and Terbinafine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol is cleared substantially by CYP2D6, so terbinafine can increase exposure to the R(+) enantiomer with alpha-blocking activity. This may cause more hypotension, dizziness and bradycardia.
What this interaction means in plain words
Carvedilol and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Terbinafine belongs to Anti Fungals.
Why it happens
CYP2D6 inhibition by terbinafine reduces carvedilol metabolism.
What to do
Monitor blood pressure and heart rate, especially at start of terbinafine, and reduce carvedilol dose if symptomatic hypotension or bradycardia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Terbinafine
- Terbinafine + Thioridazine Contraindicated
- Desipramine + Terbinafine Major
- Eliglustat + Terbinafine Major
- Flecainide + Terbinafine Major
- Imipramine + Terbinafine Major
- Maprotiline + Terbinafine Major
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Terbinafine?
MediHelp rates the interaction as moderate. Carvedilol and Terbinafine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol is cleared substantially by CYP2D6, so terbinafine can increase exposure to the R(+) enantiomer with alpha-blocking activity. This may cause more hypotension, dizziness and bradycardia.
How serious is the interaction between Carvedilol and Terbinafine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate, especially at start of terbinafine, and reduce carvedilol dose if symptomatic hypotension or bradycardia occurs.
What other medicines interact with Terbinafine?
MediHelp also lists interactions of Terbinafine with, for example, Thioridazine, Desipramine, Eliglustat. The full list is on the Terbinafine page.
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