Drug interactions
Carvedilol + Tolfenamic acid
Severity: Moderate
Carvedilol and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of beta-blockers through sodium and fluid retention. Prolonged use may also impair renal function and raise potassium in susceptible patients.
What this interaction means in plain words
Carvedilol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of renal prostaglandin synthesis causes sodium retention and vasoconstriction, opposing the antihypertensive effect.
What to do
Monitor blood pressure if NSAID use continues beyond a few days and use the lowest effective dose for the shortest time. Consider paracetamol as an alternative.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Carvedilol with Tolfenamic acid?
MediHelp rates the interaction as moderate. Carvedilol and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as tolfenamic acid can blunt the antihypertensive effect of beta-blockers through sodium and fluid retention. Prolonged use may also impair renal function and raise potassium in susceptible patients.
How serious is the interaction between Carvedilol and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure if NSAID use continues beyond a few days and use the lowest effective dose for the shortest time. Consider paracetamol as an alternative.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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