Drug interactions
Carvedilol + Vardenafil
Severity: Moderate
Carvedilol and Vardenafil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vardenafil is a vasodilator, and carvedilol lowers blood pressure through beta and alpha-1 blockade. Together they can cause additive hypotension, with dizziness or syncope, particularly when starting therapy.
What this interaction means in plain words
Carvedilol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Vardenafil belongs to Genitourinary.
Why it happens
Additive vasodilatory and antihypertensive effects, including alpha-1 blockade by carvedilol and PDE5 inhibition by vardenafil.
What to do
Start vardenafil at the lowest dose in patients on carvedilol and advise rising slowly from sitting or lying. Monitor blood pressure and symptoms of postural hypotension.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vardenafil
- Amyl nitrite + Vardenafil Contraindicated
- Glyceryl trinitrate pr + Vardenafil Contraindicated
- Isosorbide dinitrate + Vardenafil Contraindicated
- Isosorbide mononitrate + Vardenafil Contraindicated
- Nicorandil + Vardenafil Contraindicated
- Nitroglycerin po + Vardenafil Contraindicated
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Vardenafil?
MediHelp rates the interaction as moderate. Carvedilol and Vardenafil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vardenafil is a vasodilator, and carvedilol lowers blood pressure through beta and alpha-1 blockade. Together they can cause additive hypotension, with dizziness or syncope, particularly when starting therapy.
How serious is the interaction between Carvedilol and Vardenafil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Start vardenafil at the lowest dose in patients on carvedilol and advise rising slowly from sitting or lying. Monitor blood pressure and symptoms of postural hypotension.
What other medicines interact with Vardenafil?
MediHelp also lists interactions of Vardenafil with, for example, Amyl nitrite, Glyceryl trinitrate pr, Isosorbide dinitrate. The full list is on the Vardenafil page.
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