Drug interactions
Carvedilol + Venetoclax
Severity: Moderate
Carvedilol and Venetoclax: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Carvedilol inhibits P-glycoprotein and may increase venetoclax exposure. This raises the risk of venetoclax toxicities such as neutropenia and tumor lysis syndrome.
What this interaction means in plain words
Carvedilol and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Carvedilol belongs to Cardiovascular; Venetoclax belongs to Miscellaneous.
Why it happens
Carvedilol inhibits P-glycoprotein efflux of venetoclax, increasing its absorption.
What to do
Where possible choose an alternative to carvedilol. If it is used, consider reducing the venetoclax dose per labeling and monitor blood counts and tumor lysis laboratory markers.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Carvedilol
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
Frequently asked questions
Can I take Carvedilol with Venetoclax?
MediHelp rates the interaction as moderate. Carvedilol and Venetoclax can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Carvedilol inhibits P-glycoprotein and may increase venetoclax exposure. This raises the risk of venetoclax toxicities such as neutropenia and tumor lysis syndrome.
How serious is the interaction between Carvedilol and Venetoclax?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Where possible choose an alternative to carvedilol. If it is used, consider reducing the venetoclax dose per labeling and monitor blood counts and tumor lysis laboratory markers.
What other medicines interact with Carvedilol?
MediHelp also lists interactions of Carvedilol with, for example, Amifostine, Amiodarone, Arformoterol. The full list is on the Carvedilol page.
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