Drug interactions
Venetoclax + Voriconazole
Severity: Contraindicated
Venetoclax and Voriconazole: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voriconazole increases venetoclax exposure, raising the risk of tumor lysis syndrome and neutropenia, especially during dose ramp-up. After ramp-up the combination may be used only with a substantial venetoclax dose reduction.
What this interaction means in plain words
Venetoclax and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Venetoclax belongs to Miscellaneous; Voriconazole belongs to Anti Fungals.
Why it happens
Strong CYP3A4 inhibition (and possible P-gp inhibition) reduces venetoclax clearance.
What to do
Avoid during initiation and ramp-up in CLL/SLL. After ramp-up, reduce venetoclax dose per labeling and monitor blood counts and for toxicity.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Voriconazole
- Avanafil + Voriconazole Contraindicated
- Butabarbital + Voriconazole Contraindicated
- Carbamazepine + Voriconazole Contraindicated
- Conivaptan + Voriconazole Contraindicated
- Dihydroergotamine intranasal + Voriconazole Contraindicated
- Dihydroergotamine + Voriconazole Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Posaconazole + Venetoclax Contraindicated
- Amiodarone + Venetoclax Major
- Apalutamide + Venetoclax Major
Frequently asked questions
Can I take Venetoclax with Voriconazole?
MediHelp rates the interaction as contraindicated. Venetoclax and Voriconazole are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Voriconazole increases venetoclax exposure, raising the risk of tumor lysis syndrome and neutropenia, especially during dose ramp-up. After ramp-up the combination may be used only with a substantial venetoclax dose reduction.
How serious is the interaction between Venetoclax and Voriconazole?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid during initiation and ramp-up in CLL/SLL. After ramp-up, reduce venetoclax dose per labeling and monitor blood counts and for toxicity.
What other medicines interact with Voriconazole?
MediHelp also lists interactions of Voriconazole with, for example, Avanafil, Butabarbital, Carbamazepine. The full list is on the Voriconazole page.
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