Drug interactions
Posaconazole + Venetoclax
Severity: Contraindicated
Posaconazole and Venetoclax: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole significantly increases venetoclax exposure, raising the risk of tumor lysis syndrome during ramp-up and of neutropenia and other toxicity afterward.
What this interaction means in plain words
Posaconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Posaconazole belongs to Anti Fungals; Venetoclax belongs to Miscellaneous.
Why it happens
Posaconazole strongly inhibits CYP3A4 and may inhibit P-glycoprotein, reducing venetoclax clearance.
What to do
Do not use during venetoclax initiation and ramp-up. After ramp-up, reduce the venetoclax dose per labeling (substantially) and monitor for toxicity and blood counts.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Other interactions of Venetoclax
- Clarithromycin + Venetoclax Contraindicated
- Itraconazole + Venetoclax Contraindicated
- Ketoconazole + Venetoclax Contraindicated
- Venetoclax + Voriconazole Contraindicated
- Amiodarone + Venetoclax Major
- Apalutamide + Venetoclax Major
Frequently asked questions
Can I take Posaconazole with Venetoclax?
MediHelp rates the interaction as contraindicated. Posaconazole and Venetoclax are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Posaconazole significantly increases venetoclax exposure, raising the risk of tumor lysis syndrome during ramp-up and of neutropenia and other toxicity afterward.
How serious is the interaction between Posaconazole and Venetoclax?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not use during venetoclax initiation and ramp-up. After ramp-up, reduce the venetoclax dose per labeling (substantially) and monitor for toxicity and blood counts.
What other medicines interact with Posaconazole?
MediHelp also lists interactions of Posaconazole with, for example, Artemether, Avanafil, Cobimetinib. The full list is on the Posaconazole page.
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