Drug interactions
Carvedilol + Zafirlukast
Severity: Minor
Carvedilol and Zafirlukast: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Zafirlukast inhibits CYP2C9 and carvedilol is partly cleared by CYP2C9 and CYP2D6, so carvedilol levels may increase slightly. This could add to bradycardia or hypotension, though the effect is probably small.
What this interaction means in plain words
Carvedilol and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Carvedilol belongs to Cardiovascular; Zafirlukast belongs to Respiratory.
Why it happens
Zafirlukast inhibits CYP2C9, reducing metabolism of the R-carvedilol enantiomer.
What to do
Monitor heart rate and blood pressure after starting zafirlukast. Adjust carvedilol only if symptomatic.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Zafirlukast
- Pimozide + Zafirlukast Contraindicated
- Lomitapide + Zafirlukast Major
- Nilotinib + Zafirlukast Major
- Warfarin + Zafirlukast Major
- Apalutamide + Zafirlukast Moderate
- Carbamazepine + Zafirlukast Moderate
Other interactions of Carvedilol
Frequently asked questions
Can I take Carvedilol with Zafirlukast?
MediHelp rates the interaction as minor. Carvedilol and Zafirlukast have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Zafirlukast inhibits CYP2C9 and carvedilol is partly cleared by CYP2C9 and CYP2D6, so carvedilol levels may increase slightly. This could add to bradycardia or hypotension, though the effect is probably small.
How serious is the interaction between Carvedilol and Zafirlukast?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure after starting zafirlukast. Adjust carvedilol only if symptomatic.
What other medicines interact with Zafirlukast?
MediHelp also lists interactions of Zafirlukast with, for example, Pimozide, Lomitapide, Nilotinib. The full list is on the Zafirlukast page.
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