Drug interactions
Cedazuridine + Gemcitabine
Severity: Major
Cedazuridine and Gemcitabine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cedazuridine inhibits cytidine deaminase, the main enzyme that inactivates gemcitabine. Gemcitabine exposure and toxicity, including myelosuppression, may therefore be increased.
What this interaction means in plain words
Cedazuridine and Gemcitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of cytidine deaminase reduces gemcitabine metabolism to inactive difluorodeoxyuridine.
What to do
Avoid combining unless a specific protocol supports it. If unavoidable, monitor blood counts closely and reduce the gemcitabine dose as clinically indicated.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Gemcitabine
Frequently asked questions
Can I take Cedazuridine with Gemcitabine?
MediHelp rates the interaction as major. Cedazuridine and Gemcitabine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Cedazuridine inhibits cytidine deaminase, the main enzyme that inactivates gemcitabine. Gemcitabine exposure and toxicity, including myelosuppression, may therefore be increased.
How serious is the interaction between Cedazuridine and Gemcitabine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combining unless a specific protocol supports it. If unavoidable, monitor blood counts closely and reduce the gemcitabine dose as clinically indicated.
What other medicines interact with Gemcitabine?
MediHelp also lists interactions of Gemcitabine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Gemcitabine page.
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