Drug reference
gemcitabine
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Drug class
Oncology (Anti Metabolite)
Mechanism of action
Pyrimidine analog; inhibits DNA synthesis by inhibiting the ribonucleotide reductase, cell cycle-specific for the S-phase of the cycle (also blocks cellular progression at G1/S-phase) Metabolized by nucleoside kinases to diphosphate (dFdCDP) and triphosphate (dFdCTP) nucleosides
Common side effects
- Neutropenia
- Anemia
- Leukopenia
- Vomiting
- Nausea
- Pain
- Elevated LFTs
Related conditions
Frequently asked questions
What drug class is gemcitabine?
gemcitabine belongs to: Oncology.
How does gemcitabine work?
Pyrimidine analog; inhibits DNA synthesis by inhibiting the ribonucleotide reductase, cell cycle-specific for the S-phase of the cycle (also blocks cellular progression at G1/S-phase) Metabolized by nucleoside kinases to diphosphate (dFdCDP) and triphosphate (dFdCTP) nucleosides
What are the common side effects of gemcitabine?
Neutropenia, Anemia, Leukopenia, Vomiting, Nausea, Pain, Elevated LFTs
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