Drug interactions
Cefaclor + Dexamethasone-tobramycin
Severity: Minor
Cefaclor and Dexamethasone-tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent cephalosporin and aminoglycoside therapy has been associated with additive kidney injury, mainly with some cephalosporins and in at-risk patients. Oral cefaclor has little nephrotoxic potential, so the risk is small.
What this interaction means in plain words
Cefaclor and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefaclor belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity; mechanism not firmly established for this cephalosporin.
What to do
Monitor renal function and tobramycin levels as usual during aminoglycoside therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefaclor with Dexamethasone-tobramycin?
MediHelp rates the interaction as minor. Cefaclor and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Concurrent cephalosporin and aminoglycoside therapy has been associated with additive kidney injury, mainly with some cephalosporins and in at-risk patients. Oral cefaclor has little nephrotoxic potential, so the risk is small.
How serious is the interaction between Cefaclor and Dexamethasone-tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and tobramycin levels as usual during aminoglycoside therapy.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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