Drug interactions
Cefaclor + Plazomicin
Severity: Moderate
Cefaclor and Plazomicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Plazomicin carries warnings for nephrotoxicity, ototoxicity and neuromuscular blockade. Cephalosporins have occasionally been associated with additive kidney injury when combined with aminoglycosides, although cefaclor has relatively low nephrotoxic potential.
What this interaction means in plain words
Cefaclor and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefaclor belongs to Anti Bacterial; Plazomicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic effects on the renal tubule.
What to do
Monitor serum creatinine and plazomicin concentrations during combined use, and adjust the plazomicin dose to renal function per labeling.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
- Cefaclor + Typhoid vaccine live Moderate
Other interactions of Plazomicin
- Cefadroxil + Plazomicin Moderate
- Cefalexin + Plazomicin Moderate
- Cefazolin + Plazomicin Moderate
- Cefditoren + Plazomicin Moderate
- Cefepime + Plazomicin Moderate
- Cefixime + Plazomicin Moderate
Frequently asked questions
Can I take Cefaclor with Plazomicin?
MediHelp rates the interaction as moderate. Cefaclor and Plazomicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Plazomicin carries warnings for nephrotoxicity, ototoxicity and neuromuscular blockade. Cephalosporins have occasionally been associated with additive kidney injury when combined with aminoglycosides, although cefaclor has relatively low nephrotoxic potential.
How serious is the interaction between Cefaclor and Plazomicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and plazomicin concentrations during combined use, and adjust the plazomicin dose to renal function per labeling.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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