Drug interactions
Cefaclor + Mestranol
Severity: Minor
Cefaclor and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotics have been theorised to lower oral contraceptive efficacy. Mestranol is a prodrug of ethinylestradiol, and clinical data show no consistent loss of contraceptive protection with non-rifamycin antibiotics.
What this interaction means in plain words
Cefaclor and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of gut flora involved in estrogen enterohepatic recirculation.
What to do
No routine additional contraception is required; advise backup methods if vomiting or severe diarrhoea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefaclor with Mestranol?
MediHelp rates the interaction as minor. Cefaclor and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Antibiotics have been theorised to lower oral contraceptive efficacy. Mestranol is a prodrug of ethinylestradiol, and clinical data show no consistent loss of contraceptive protection with non-rifamycin antibiotics.
How serious is the interaction between Cefaclor and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine additional contraception is required; advise backup methods if vomiting or severe diarrhoea occurs.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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