Drug interactions
Cefaclor + Neomycin po
Severity: Minor
Cefaclor and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic nephrotoxicity and ototoxicity are uncommon, but absorption can increase with inflamed bowel or renal impairment. Concurrent cefaclor adds little in most patients.
What this interaction means in plain words
Cefaclor and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive nephrotoxicity if neomycin is systemically absorbed.
What to do
No action is usually needed; monitor renal function if the patient has renal impairment, bowel inflammation or prolonged neomycin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefaclor with Neomycin po?
MediHelp rates the interaction as minor. Cefaclor and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so systemic nephrotoxicity and ototoxicity are uncommon, but absorption can increase with inflamed bowel or renal impairment. Concurrent cefaclor adds little in most patients.
How serious is the interaction between Cefaclor and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually needed; monitor renal function if the patient has renal impairment, bowel inflammation or prolonged neomycin use.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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