Drug interactions
Cefaclor + Typhoid vaccine live
Severity: Moderate
Cefaclor and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine contains viable Salmonella Typhi that must colonize the gut to induce immunity. Cefaclor has some Gram-negative activity and may reduce vaccine strain viability and the immune response.
What this interaction means in plain words
Cefaclor and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may reduce survival of the live attenuated Salmonella vaccine strain.
What to do
Delay the live typhoid vaccine until the antibiotic course has finished, or use the inactivated injectable vaccine if vaccination cannot wait.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefaclor
- Bcg vaccine live + Cefaclor Moderate
- Cefaclor + Cholera vaccine Moderate
- Cefaclor + Kanamycin Moderate
- Cefaclor + Microbiota Moderate
- Cefaclor + Plazomicin Moderate
- Cefaclor + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefaclor with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Cefaclor and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine contains viable Salmonella Typhi that must colonize the gut to induce immunity. Cefaclor has some Gram-negative activity and may reduce vaccine strain viability and the immune response.
How serious is the interaction between Cefaclor and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay the live typhoid vaccine until the antibiotic course has finished, or use the inactivated injectable vaccine if vaccination cannot wait.
What other medicines interact with Cefaclor?
MediHelp also lists interactions of Cefaclor with, for example, Bcg vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefaclor page.
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