Drug interactions
Cefadroxil + Ibuprofen
Severity: Minor
Cefadroxil and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefadroxil is renally secreted by anionic transporters, and ibuprofen is also an organic anion, so competition is theoretically possible. Any effect on ibuprofen levels is small and not clinically important in most patients.
What this interaction means in plain words
Cefadroxil and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Ibuprofen belongs to Musculoskeletal.
Why it happens
Theoretical competition for renal tubular organic anion secretion.
What to do
No action is generally needed. Consider renal function in patients with impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Ibuprofen?
MediHelp rates the interaction as minor. Cefadroxil and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefadroxil is renally secreted by anionic transporters, and ibuprofen is also an organic anion, so competition is theoretically possible. Any effect on ibuprofen levels is small and not clinically important in most patients.
How serious is the interaction between Cefadroxil and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally needed. Consider renal function in patients with impairment.
What other medicines interact with Ibuprofen?
MediHelp also lists interactions of Ibuprofen with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Ibuprofen page.
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