Drug interactions
Cefadroxil + Tobramycin
Severity: Moderate
Cefadroxil and Tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tobramycin is nephrotoxic and ototoxic, and cephalosporins have occasionally been linked to additional kidney injury when combined. Oral cefadroxil has low nephrotoxic potential, so the added risk is generally small.
What this interaction means in plain words
Cefadroxil and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefadroxil belongs to Anti Bacterial; Tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive renal tubular injury; aminoglycoside toxicity is the dominant contributor.
What to do
Monitor serum creatinine and tobramycin levels during therapy. Adjust the tobramycin dose to renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Other interactions of Tobramycin
- Cidofovir + Tobramycin Contraindicated
- Adefovir + Tobramycin Major
- Amikacin + Tobramycin Major
- Amphotericin b deoxycholate + Tobramycin Major
- Amphotericin b + Tobramycin Major
- Atracurium + Tobramycin Major
Frequently asked questions
Can I take Cefadroxil with Tobramycin?
MediHelp rates the interaction as moderate. Cefadroxil and Tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tobramycin is nephrotoxic and ototoxic, and cephalosporins have occasionally been linked to additional kidney injury when combined. Oral cefadroxil has low nephrotoxic potential, so the added risk is generally small.
How serious is the interaction between Cefadroxil and Tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and tobramycin levels during therapy. Adjust the tobramycin dose to renal function.
What other medicines interact with Cefadroxil?
MediHelp also lists interactions of Cefadroxil with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefadroxil page.
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