Drug interactions
Cefadroxil + Tolmetin
Severity: Minor
Cefadroxil and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic anions eliminated partly by tubular secretion, so they may compete for renal excretion. Tolmetin exposure could rise slightly, but the clinical effect is expected to be small.
What this interaction means in plain words
Cefadroxil and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefadroxil belongs to Anti Bacterial; Tolmetin belongs to Musculoskeletal.
Why it happens
Competition for renal tubular anion secretion (OAT transporters) reduces clearance.
What to do
No routine action is needed; be aware of possible enhanced NSAID effects in patients with reduced renal function.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Other interactions of Cefadroxil
- Amikacin + Cefadroxil Moderate
- Avelumab + Cefadroxil Moderate
- Balstilimab + Cefadroxil Moderate
- Bcg vaccine live + Cefadroxil Moderate
- Cefadroxil + Cholera vaccine Moderate
- Cefadroxil + Gentamicin Moderate
Frequently asked questions
Can I take Cefadroxil with Tolmetin?
MediHelp rates the interaction as minor. Cefadroxil and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic anions eliminated partly by tubular secretion, so they may compete for renal excretion. Tolmetin exposure could rise slightly, but the clinical effect is expected to be small.
How serious is the interaction between Cefadroxil and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed; be aware of possible enhanced NSAID effects in patients with reduced renal function.
What other medicines interact with Tolmetin?
MediHelp also lists interactions of Tolmetin with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Tolmetin page.
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