Drug interactions
Cefalexin + Celecoxib
Severity: Minor
Cefalexin and Celecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs undergo some renal tubular secretion, but celecoxib is mainly cleared by hepatic metabolism, so a relevant change in exposure is unlikely. No clinically significant interaction is established.
What this interaction means in plain words
Cefalexin and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefalexin belongs to Anti Bacterial; Celecoxib belongs to Musculoskeletal.
Why it happens
Theoretical competition for renal tubular secretion, of doubtful relevance for celecoxib.
What to do
No dose adjustment is needed. Monitor renal function in patients at risk of kidney injury.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Kanamycin Moderate
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Cefalexin with Celecoxib?
MediHelp rates the interaction as minor. Cefalexin and Celecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs undergo some renal tubular secretion, but celecoxib is mainly cleared by hepatic metabolism, so a relevant change in exposure is unlikely. No clinically significant interaction is established.
How serious is the interaction between Cefalexin and Celecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is needed. Monitor renal function in patients at risk of kidney injury.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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