Drug interactions
Cefalexin + Chlorothiazide
Severity: Minor
Cefalexin and Chlorothiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are secreted by renal tubular anion transport, so cefalexin may slightly slow chlorothiazide elimination. The effect is theoretical and unlikely to matter in practice.
What this interaction means in plain words
Cefalexin and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefalexin belongs to Anti Bacterial; Chlorothiazide belongs to Cardiovascular.
Why it happens
Possible competition for renal tubular anion secretion; clinical relevance is unproven.
What to do
No adjustment is required. Monitor serum electrolytes and fluid status as part of routine diuretic care.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Kanamycin Moderate
Other interactions of Chlorothiazide
Frequently asked questions
Can I take Cefalexin with Chlorothiazide?
MediHelp rates the interaction as minor. Cefalexin and Chlorothiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both agents are secreted by renal tubular anion transport, so cefalexin may slightly slow chlorothiazide elimination. The effect is theoretical and unlikely to matter in practice.
How serious is the interaction between Cefalexin and Chlorothiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No adjustment is required. Monitor serum electrolytes and fluid status as part of routine diuretic care.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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