Drug interactions
Cefalexin + Sulindac
Severity: Minor
Cefalexin and Sulindac: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefalexin and the active sulindac metabolites are organic acids that may compete for tubular secretion. The effect on sulindac exposure is theoretical and probably small.
What this interaction means in plain words
Cefalexin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefalexin belongs to Anti Bacterial; Sulindac belongs to Musculoskeletal.
Why it happens
Theoretical competition for renal tubular organic anion secretion.
What to do
No dose change is needed. Monitor renal function if the patient is elderly or has kidney disease, since NSAIDs themselves can affect the kidney.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefalexin
- Amikacin + Cefalexin Moderate
- Avelumab + Cefalexin Moderate
- Balstilimab + Cefalexin Moderate
- Bcg vaccine live + Cefalexin Moderate
- Cefalexin + Cholera vaccine Moderate
- Cefalexin + Kanamycin Moderate
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Cefalexin with Sulindac?
MediHelp rates the interaction as minor. Cefalexin and Sulindac have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefalexin and the active sulindac metabolites are organic acids that may compete for tubular secretion. The effect on sulindac exposure is theoretical and probably small.
How serious is the interaction between Cefalexin and Sulindac?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is needed. Monitor renal function if the patient is elderly or has kidney disease, since NSAIDs themselves can affect the kidney.
What other medicines interact with Cefalexin?
MediHelp also lists interactions of Cefalexin with, for example, Amikacin, Avelumab, Balstilimab. The full list is on the Cefalexin page.
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