Drug interactions
Cefamandole + Diflunisal
Severity: Moderate
Cefamandole and Diflunisal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefamandole can cause hypoprothrombinemia and impair platelet function, which could increase bleeding risk with NSAIDs such as diflunisal. Competition for renal tubular secretion may also modestly raise diflunisal levels.
What this interaction means in plain words
Cefamandole and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive effects on hemostasis (cephalosporin-related vitamin K antagonism and NSAID platelet inhibition) and competition for renal tubular secretion.
What to do
Monitor for bleeding and consider monitoring INR if used in patients at risk. Use gastroprotection if long-term NSAID therapy is needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Diflunisal
- Diflunisal + Ketorolac Contraindicated
- Diflunisal + Ketorolac intranasal Contraindicated
- Acemetacin + Diflunisal Major
- Acetazolamide + Diflunisal Major
- Alteplase + Diflunisal Major
- Amiloride + Diflunisal Major
Frequently asked questions
Can I take Cefamandole with Diflunisal?
MediHelp rates the interaction as moderate. Cefamandole and Diflunisal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cefamandole can cause hypoprothrombinemia and impair platelet function, which could increase bleeding risk with NSAIDs such as diflunisal. Competition for renal tubular secretion may also modestly raise diflunisal levels.
How serious is the interaction between Cefamandole and Diflunisal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding and consider monitoring INR if used in patients at risk. Use gastroprotection if long-term NSAID therapy is needed.
What other medicines interact with Diflunisal?
MediHelp also lists interactions of Diflunisal with, for example, Ketorolac, Ketorolac intranasal, Acemetacin. The full list is on the Diflunisal page.
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