Drug interactions
Cefamandole + Indomethacin
Severity: Minor
Cefamandole and Indomethacin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic acids that are secreted by renal tubular transporters, so cefamandole could modestly slow indomethacin elimination. The clinical consequence is poorly documented and probably small.
What this interaction means in plain words
Cefamandole and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal tubular anionic secretion (OAT pathway), which is theoretical and not well characterized.
What to do
No routine change is needed. Watch for increased NSAID adverse effects such as GI upset or fluid retention in patients with renal impairment.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Cefamandole with Indomethacin?
MediHelp rates the interaction as minor. Cefamandole and Indomethacin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic acids that are secreted by renal tubular transporters, so cefamandole could modestly slow indomethacin elimination. The clinical consequence is poorly documented and probably small.
How serious is the interaction between Cefamandole and Indomethacin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Watch for increased NSAID adverse effects such as GI upset or fluid retention in patients with renal impairment.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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