Drug interactions
Cefamandole + Ketoprofen
Severity: Minor
Cefamandole and Ketoprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefamandole is cleared by renal tubular secretion, and ketoprofen may compete for this pathway. Cefamandole can also impair coagulation through hypoprothrombinemia, and with an NSAID's antiplatelet action the bleeding risk may rise.
What this interaction means in plain words
Cefamandole and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal organic anion tubular secretion, plus additive hemostatic effects.
What to do
No routine adjustment is needed; monitor for bleeding in patients with poor nutrition, renal impairment or other bleeding risk factors.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Cefamandole with Ketoprofen?
MediHelp rates the interaction as minor. Cefamandole and Ketoprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefamandole is cleared by renal tubular secretion, and ketoprofen may compete for this pathway. Cefamandole can also impair coagulation through hypoprothrombinemia, and with an NSAID's antiplatelet action the bleeding risk may rise.
How serious is the interaction between Cefamandole and Ketoprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor for bleeding in patients with poor nutrition, renal impairment or other bleeding risk factors.
What other medicines interact with Ketoprofen?
MediHelp also lists interactions of Ketoprofen with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Ketoprofen page.
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