Drug interactions
Cefamandole + Mesalamine
Severity: Minor
Cefamandole and Mesalamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are organic anions handled by renal tubular secretion, so cefamandole could in theory slow elimination of mesalamine metabolites. No clinically meaningful change in mesalamine effect or toxicity has been established.
What this interaction means in plain words
Cefamandole and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical competition for renal tubular organic anion secretion.
What to do
No routine action is needed. Monitor renal function if prolonged mesalamine therapy is given with high-dose cephalosporins.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Mesalamine
Frequently asked questions
Can I take Cefamandole with Mesalamine?
MediHelp rates the interaction as minor. Cefamandole and Mesalamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are organic anions handled by renal tubular secretion, so cefamandole could in theory slow elimination of mesalamine metabolites. No clinically meaningful change in mesalamine effect or toxicity has been established.
How serious is the interaction between Cefamandole and Mesalamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor renal function if prolonged mesalamine therapy is given with high-dose cephalosporins.
What other medicines interact with Mesalamine?
MediHelp also lists interactions of Mesalamine with, for example, Measles mumps rubella and varicella vaccine live, Varicella virus vaccine live, Aceclofenac. The full list is on the Mesalamine page.
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