Drug interactions
Cefamandole + Probenecid
Severity: Minor
Cefamandole and Probenecid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces tubular secretion of cefamandole, increasing and prolonging its serum levels. This is sometimes used deliberately to boost antibiotic exposure but may increase dose-related adverse effects.
What this interaction means in plain words
Cefamandole and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Probenecid inhibits OAT-mediated renal tubular secretion of cefamandole.
What to do
No action is usually required; reduce the cefamandole dose in renal impairment and monitor for adverse effects if both are used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Cefamandole with Probenecid?
MediHelp rates the interaction as minor. Cefamandole and Probenecid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Probenecid reduces tubular secretion of cefamandole, increasing and prolonging its serum levels. This is sometimes used deliberately to boost antibiotic exposure but may increase dose-related adverse effects.
How serious is the interaction between Cefamandole and Probenecid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is usually required; reduce the cefamandole dose in renal impairment and monitor for adverse effects if both are used.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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