Drug interactions
Cefazolin + Typhoid vaccine live
Severity: Moderate
Cefazolin and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral live typhoid vaccine contains viable Salmonella Typhi that must colonize the gut to induce immunity. Parenteral antibacterials could theoretically reduce its viability, but cefazolin has modest Gram-negative activity and the effect is largely theoretical.
What this interaction means in plain words
Cefazolin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibacterial activity may reduce survival of the live attenuated Salmonella vaccine strain.
What to do
Delay the live typhoid vaccine until the antibiotic course has finished, or use the inactivated injectable vaccine if vaccination cannot wait.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefazolin
- Amikacin + Cefazolin Moderate
- Bcg vaccine live + Cefazolin Moderate
- Cefazolin + Cholera vaccine Moderate
- Cefazolin + Dexamethasone-tobramycin Moderate
- Cefazolin + Gentamicin Moderate
- Cefazolin + Kanamycin Moderate
Frequently asked questions
Can I take Cefazolin with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Cefazolin and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oral live typhoid vaccine contains viable Salmonella Typhi that must colonize the gut to induce immunity. Parenteral antibacterials could theoretically reduce its viability, but cefazolin has modest Gram-negative activity and the effect is largely theoretical.
How serious is the interaction between Cefazolin and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Delay the live typhoid vaccine until the antibiotic course has finished, or use the inactivated injectable vaccine if vaccination cannot wait.
What other medicines interact with Cefazolin?
MediHelp also lists interactions of Cefazolin with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefazolin page.
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