Drug interactions
Cefepime + Neomycin po
Severity: Minor
Cefepime and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed in healthy gut, so systemic exposure is usually small. Absorption can increase with inflamed or damaged bowel mucosa or renal impairment, and then additive kidney and ear toxicity with cefepime becomes conceivable.
What this interaction means in plain words
Cefepime and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive nephrotoxicity if systemic neomycin absorption occurs.
What to do
Monitor renal function in patients with renal impairment, bowel inflammation, or prolonged neomycin use, and adjust cefepime dose to creatinine clearance.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefepime
- Amikacin + Cefepime Moderate
- Cefepime + Cholera vaccine Moderate
- Cefepime + Dexamethasone-tobramycin Moderate
- Cefepime + Gentamicin Moderate
- Cefepime + Kanamycin Moderate
- Cefepime + Microbiota Moderate
Frequently asked questions
Can I take Cefepime with Neomycin po?
MediHelp rates the interaction as minor. Cefepime and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed in healthy gut, so systemic exposure is usually small. Absorption can increase with inflamed or damaged bowel mucosa or renal impairment, and then additive kidney and ear toxicity with cefepime becomes conceivable.
How serious is the interaction between Cefepime and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function in patients with renal impairment, bowel inflammation, or prolonged neomycin use, and adjust cefepime dose to creatinine clearance.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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